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KMID : 0614020000160010084
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Journal of Pharmaceutical Sciences (C.N.U.)
2000 Volume.16 No. 1 p.84 ~ p.88
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Pharmacokinetic Study of Epigallocatechin Gallate from Green Tea Extracts in Sprague-Dawley Rats
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Lim Jae-Soo
Hwang Sung-Joo
Jee Ung-Kil
Kim Dong-Chool
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Abstract
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The pharmcacokinetic study of epigallocatechin gallate was performed following iv bolus administration in Sprague-Dawley rats. The values of systemic clearance (CL) were 68±5 and 27±1 ml/min/kg following iv bolus administration of 1 mg and 5 mg EGCG, respectively. The values of volume of distribution at steady state were 380 and 835 ml/kg body weight after iv bolus administration 1mg and 5mg EGCG, respectively. The decrease in the value of CL and the increase of Vss as a function of dose suggest saturable pharmacokinetics of EGCG in rats.
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KEYWORD
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Epigallocatechin gallagte, pharmacokinetics, rats
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